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Celecoxib and heterotopic bone formation after total hip arthroplasty

Carlos J Lavernia1, Juan S Contreras2, Jesus M Villa2

  • 1Orthopaedic Institute at Mercy Hospital, Miami, Florida.

The Journal of Arthroplasty
|August 10, 2013
PubMed

Insights

Celecoxib effectively prevents heterotopic ossification after total hip replacement. This short-term pain management option is safe and does not affect anticoagulation.

Area of Science:

  • Orthopedic Surgery
  • Pharmacology

Background:

  • Heterotopic ossification (HO) is a common complication following total hip replacement (THR).
  • Preventing HO can improve patient outcomes and reduce revision rates.

Purpose of the Study:

  • To evaluate the efficacy of celecoxib in preventing HO after primary THR.
  • To assess the safety and impact on anticoagulation of celecoxib in this patient population.

Main Methods:

  • A prospective study of 170 consecutive primary THR patients.
  • Patients received either celecoxib (200mg twice daily for 28 days) or no celecoxib post-surgery.
  • HO incidence and severity (Brooker classification) were assessed at 3, 6, and 12 months.

Main Results:

  • HO was significantly less common in the celecoxib group at all follow-up points (P < 0.01).
  • Fewer celecoxib recipients developed moderate to severe HO (Brooker classes II/III) at 1 year.
  • No celecoxib patients had severe HO (Brooker class IV), compared to 2% in the control group. No treatment discontinuations or aseptic loosening revisions occurred.

Conclusions:

  • A short course of celecoxib aids in preventing HO after primary THR.
  • Celecoxib is a safe and effective option for HO prevention post-THR.
  • This treatment does not interfere with anticoagulation therapy.

Keywords:
celecoxibheterotopic ossificationpreventionprimary hip arthroplastytotal hip replacement

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