Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complex genotype-phenotype relationships shape the response to treatment of down syndrome childhood acute lymphoblastic leukaemia.

Scientific reports·2025
Same author

Multiplexed phosphoproteomics of low cell numbers using SPARCE.

Communications biology·2025
Same author

Author Correction: Fetal hepatocytes protect the HSPC genome via fetuin-A.

Nature·2025
Same author

Fetal hepatocytes protect the HSPC genome via fetuin-A.

Nature·2024
Same author

Oncogene <i>EVI1</i> drives acute myeloid leukemia via a targetable interaction with CTBP2.

Science advances·2024
Same author

Functional and molecular profiling of hematopoietic stem cells during regeneration.

Experimental hematology·2023
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
Same journal

Tracking Satb2-positive retinal ganglion cells in zebrafish unveils developmental functional reorganization.

Current biology : CB·2026
Same journal

RhoGAP54D promotes cell size asymmetry and inhibits pulsatile myosin activity in Drosophila neural stem cells.

Current biology : CB·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Lineage specification: reading the instructions may help!

Gill May1, Tariq Enver

  • 1UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK. g.may@ucl.ac.uk

Current Biology : CB
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

Cytokine signaling can instruct lineage choice in blood stem cells, a key finding for regenerative medicine. This research clarifies how extrinsic cues direct cell development and production.

More Related Videos

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo
09:18

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo

Published on: April 21, 2022

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Related Experiment Videos

Last Updated: May 9, 2026

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo
09:18

Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo

Published on: April 21, 2022

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Understanding how stem cells develop into specific cell types (lineage specification) is crucial for regenerative medicine.
  • The role of external signals (extrinsic cues) in directing this process is debated: do they guide development or select from existing possibilities?

Purpose of the Study:

  • To investigate whether extrinsic cues, specifically cytokine signaling, can actively instruct lineage decisions in blood stem cells.
  • To address the fundamental question of whether extrinsic cues direct or select cell lineages.

Main Methods:

  • Utilized single-cell analysis techniques to examine blood stem cell behavior.
  • Focused on the impact of cytokine signaling pathways on lineage commitment.

Main Results:

  • Single-cell analysis provides evidence that cytokine signaling actively instructs lineage choice.
  • Findings suggest a directive role for extrinsic cues in blood stem cell differentiation.

Conclusions:

  • Cytokine signaling is a key mechanism that instructs lineage specification in blood stem cells.
  • This understanding is critical for advancing cell production for regenerative medicine applications.