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Updated: May 9, 2026
10:18
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[Large granular lymphocyte leukemia: clinical and pathogenic aspects].
E Lazaro1, P Duffau, S Chaigne Delalande
1Service de médecine interne, hôpital du Haut Lévêque, avenue Magellan, 33604 Pessac, France. estibaliz.lazaro@chu-bordeaux.fr
La Revue De Medecine Interne
|August 10, 2013
Summary
Large granular lymphocyte leukemia (LGL) involves abnormal T or NK cells. Indolent forms often require treatment for infections, while aggressive types have a poor prognosis.
Area of Science:
- Hematology
- Immunology
- Oncology
Context:
- Large granular lymphocyte leukemia (LGL) is a hematologic disorder.
- Characterized by monoclonal expansion of T or NK cells with specific phenotypes.
- WHO classification defines three entities: T LGL, chronic NK-cell lymphoproliferative disorder, and aggressive NK-cell leukemia.
Purpose:
- To provide an overview of Large Granular Lymphocyte Leukemia (LGL).
- To discuss the classification, clinical features, and management of LGL subtypes.
- To highlight the current understanding and future therapeutic perspectives.
Summary:
- T LGL and chronic NK-cell disorders are indolent, often presenting with cytopenias and autoimmune issues.
- Neutropenia in these indolent forms can lead to infections, necessitating immunosuppressive therapy.
- Aggressive NK-cell leukemia is a rapidly progressing disease with a poor prognosis and limited treatment options.
Impact:
- Understanding LGL pathophysiology is crucial for developing novel therapeutic strategies.
- Improved classification aids in differentiating indolent from aggressive forms for tailored treatment.
- Focus on pathophysiology offers hope for better management of refractory aggressive NK-cell leukemia.
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