Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemodynamic changes during sedation in ponies.

F Gasthuys1, A De Moor, D Parmentier

  • 1Large Animal Surgical Clinic, Faculty of Veterinary Medicine, State University of Gent, Belgium.

Veterinary Research Communications
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same author

First Exclusive Reconstruction of the B^{*+}, B^{*0}, and B_{s}^{*0} Mesons and Precise Measurement of Their Masses.

Physical review letters·2026
Same journal

Host-derived Limosilactobacillus reuteri supplementation improves piglet growth and gut integrity in heat-stressed sows.

Veterinary research communications·2026
Same journal

First case of canine paraprostatic infection caused by a high-risk ST147 Klebsiella pneumoniae harboring multiple extended-spectrum-β-lactamase genes.

Veterinary research communications·2026
Same journal

Behavioral responses of pigs to dietary alternatives to antibiotic growth promoters: a systematic review.

Veterinary research communications·2026
Same journal

Serological and molecular detection of Leptospira spp. in ring-tailed coatis (Nasua nasua) from an Ecological Park.

Veterinary research communications·2026
Same journal

Molecular detection and phylogenetic characterization of Ehrlichia- and Anaplasma-related genotypes in free-ranging anteaters from southeastern Brazil.

Veterinary research communications·2026
Same journal

Clinical investigation of plasma HIF-1α and inflammatory biomarkers in dogs with thoracolumbar intervertebral disc disease receiving acupuncture treatment.

Veterinary research communications·2026
See all related articles

The atropine-xylazine combination provided the best cardiovascular stability in ponies, causing only minor, temporary changes. Other sedatives like phenothiazines and alpha-2 agonists caused prolonged or transient cardiovascular depression.

Area of Science:

  • Veterinary Anesthesiology
  • Cardiovascular Pharmacology

Background:

  • Sedatives are crucial for animal anesthesia.
  • Understanding their cardiovascular effects is vital for patient safety.
  • Phenothiazines and alpha-2 agonists are commonly used sedatives with varying effects.

Purpose of the Study:

  • To investigate the cardiovascular effects of different sedatives in ponies.
  • To compare the efficacy and safety of propionylpromazine, promethazine, xylazine, detomidine, and atropine.
  • To determine the optimal premedication protocol for general anesthesia in ponies.

Main Methods:

  • Cardiac output (thermodilution), systemic and pulmonary artery pressures (direct intravascular), and arterial blood gases/packed cell volume were measured in five ponies.
  • Cardiovascular parameters were monitored after intravenous administration of propionylpromazine, promethazine, xylazine, detomidine, and atropine, individually and in combination.

Related Experiment Videos

Main Results:

  • Propionylpromazine and promethazine caused prolonged cardiovascular depression (>90 min).
  • Xylazine and detomidine induced transient (approx. 15 min) hypertension, decreased cardiac output, bradycardia, and atrioventricular blocks, with detomidine causing more pronounced depression.
  • Atropine alone caused tachycardia and decreased stroke volume but prevented bradycardia/heart blocks induced by xylazine/detomidine, and potentiated their hypertensive effects. The atropine-xylazine combination resulted in minor, transient cardiovascular changes.

Conclusions:

  • The atropine-xylazine combination is a potentially superior premedication protocol for ponies undergoing general anesthesia due to minimal and transient cardiovascular effects.
  • Phenothiazines and alpha-2 agonists alone can cause significant and prolonged or transient cardiovascular depression and arrhythmias.
  • Atropine can mitigate bradycardia and heart blocks associated with alpha-2 agonists but potentiates hypertension.