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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Preeclampsia: a "nephrocentric" view.

Phyllis August1

  • 1Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY 100211, USA. paugust@med.cornell.edu

Advances in Chronic Kidney Disease
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

Preeclampsia, a pregnancy complication, involves hypertension and proteinuria. Delivery resolves symptoms, but its placental origins and kidney effects require further understanding.

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Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Pathology

Background:

  • Preeclampsia is a placental syndrome presenting with maternal hypertension and proteinuria in late pregnancy.
  • It can lead to severe maternal and fetal complications, with delivery being the only cure.
  • Nephrologists view it as a hypertensive proteinuric kidney disease, often with acute kidney injury.

Purpose of the Study:

  • To review the hypertension and kidney manifestations of preeclampsia.
  • To reconcile obstetric and nephrologic perspectives on the syndrome.
  • To highlight the role of placental factors in preeclampsia pathogenesis.

Main Methods:

  • Literature review focusing on preeclampsia's clinical and pathological aspects.
  • Synthesis of current understanding of preeclampsia's etiology and manifestations.
  • Analysis of the interplay between placental dysfunction and maternal organ systems.

Main Results:

  • Preeclampsia presents with diverse maternal symptoms, including hypertension and renal dysfunction.
  • Delivery effectively resolves preeclampsia, indicating a placental origin.
  • Ongoing research is clarifying the complex pathogenesis and reconciling different clinical views.

Conclusions:

  • Preeclampsia is a multi-system disorder with significant maternal and fetal implications.
  • Understanding placental origins is key to managing hypertension and kidney disease in preeclampsia.
  • Further research is needed to fully elucidate the syndrome's complex pathophysiology.