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PTH: a new target in arteriosclerosis?

Petra J Buizert1, Natasja M van Schoor, Suat Simsek

  • 1PhD, Internist-Endocrinologist, Department of Endocrinology, VU University Medical Center, Box 7057, 1007 MB Amsterdam, The Netherlands. emw.eekhoff@vumc.nl.

The Journal of Clinical Endocrinology and Metabolism
|August 10, 2013
PubMed

Insights

Elevated parathyroid hormone (PTH) levels within the normal range are linked to increased cardiovascular disease (CVD) risk in older adults. This association may be partly explained by abdominal aortic calcifications in men.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Geriatrics

Background:

  • Growing evidence links hyperparathyroidism to cardiovascular risks.
  • The relationship between normal serum PTH levels and cardiovascular diseases (CVD) is not well understood.

Purpose of the Study:

  • To investigate the association between serum PTH levels within the normal range and CVD.
  • To examine the link between normal serum PTH levels and abdominal aortic calcifications.

Main Methods:

  • Cross-sectional, population-based study using data from the Longitudinal Aging Study Amsterdam.
  • Included 558 men and 537 women aged 65-88 years.
  • Adjusted for multiple potential confounders including demographics, lifestyle, and biochemical factors.

Main Results:

  • Higher serum PTH levels within the normal range were significantly associated with increased CVD risk (OR 2.22).
  • A significant association between PTH and abdominal aortic calcifications was found in men (OR 4.03).
  • The association between PTH and aortic calcifications in men remained significant after confounder adjustment.

Conclusions:

  • Serum PTH levels in the upper normal range are strongly associated with CVD in older individuals.
  • Abdominal aortic calcifications may partially mediate the PTH-CVD link in men.
  • Further research is warranted to understand the role of serum PTH in CVD and arteriosclerosis.
Abstract

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