Related Experiment Video
Updated: May 9, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Aryl hydrocarbon receptor and colitis
Ivan Monteleone1, Francesco Pallone, Giovanni Monteleone
1Dipartimento di Medicina dei Sistemi, Università Tor Vergata di Roma, Via Montpellier, 1, 00133, Rome, Italy, ivan.monteleone@uniroma2.it.
Abstract:
The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large variety of natural and synthetic ligands, has recently become the object of great interest among researchers since it represents an important link between environment and immune-mediated pathologies. In this context, evidence has been accumulated to show that AhR is necessary for the maintenance/expansion of intraepithelial lymphocytes and interleukin-22-producing innate lymphoid cells in the gut and that defects in AhR-delivered signals may contribute to amplify gut tissue destructive immune-inflammatory reactions. We here review the available data supporting the role of AhR in the control of immune homeostasis in the gut and discuss whether and how AhR activators can help dampen inflammatory processes.
More Related Videos
08:37Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
08:02Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
Published on: March 12, 2020
Related Concept Videos
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease III: Crohn's Disease
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...