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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

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Abdominal pain in ulcerative colitis.

Matthew D Coates1, Mayank Lahoti, David G Binion

  • 1Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. coatesmd@upmc.edu

Inflammatory Bowel Diseases
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

Over half of ulcerative colitis (UC) patients experience abdominal pain, even without active inflammation. Factors like mood disorders and female gender also contribute, suggesting central pain mechanisms are key for UC pain management.

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Area of Science:

  • Gastroenterology
  • Pain Medicine
  • Psychiatry

Background:

  • Chronic pain is prevalent in inflammatory bowel disease (IBD), often linked to inflammation.
  • Many IBD patients experience pain despite no evidence of active disease.
  • This study investigates pain prevalence and contributing factors in ulcerative colitis (UC).

Purpose of the Study:

  • Determine the prevalence of abdominal pain in ulcerative colitis (UC) patients.
  • Examine the role of inflammation in UC-related pain.
  • Investigate the impact of psychiatric comorbidities on pain in UC.

Main Methods:

  • Retrospective cross-sectional analysis of adult UC patients at a tertiary referral center.
  • Data abstracted included demographics, disease characteristics, pain ratings, quality of life, and inflammatory markers (CRP, ESR).
  • Disease severity assessed via physician global assessment, endoscopic, and histological evaluations.

Main Results:

  • Over 50% of UC patients reported abdominal pain; 21.5% experienced frequent pain.
  • Even in quiescent disease, 10% reported frequent pain.
  • Pain correlated with physician global assessment, inflammation markers (CRP, ESR), female gender, and mood disorders.

Conclusions:

  • Abdominal pain is highly prevalent in UC, exceeding 50%.
  • While inflammation plays a role, factors like gender distribution and mood disorders suggest central pain mechanisms are significant.
  • UC pain management should integrate strategies targeting psychological factors alongside anti-inflammatory approaches.