Related Experiment Video
Updated: May 9, 2026

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
Published on: October 17, 2018
Findings of long-term depression up to 8 years post infection from West Nile virus
Melissa S Nolan1, Anne M Hause, Kristy O Murray
1The University of Texas Health Science Center, USA.
Objective:
To examine the psychological sequelae following West Nile virus (WNV) infection among a large cohort of participants over an 8-year period.
Design:
We conducted a longitudinal study to assess mental health outcomes among a cohort of 171 WNV-positive participants in Houston, Texas.
Results:
We found 35% of participants met the Center for Epidemiologic Studies Depression scale definition for new onset clinical depression. Multivariate analysis found that severe depression was significantly associated with gender and physical disability (Barthel index score <100) at 5 years post-WNV infection.
Conclusions:
Practitioners should be aware of depression as a possible outcome in patients who were infected with WNV and include this as a part of their routine assessment.
Related Concept Videos
Arboviral Encephalitis
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Encephalitis ll: Pathophysiology
Encephalitis l: Introduction

