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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...

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Updated: May 9, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

On the increase in network robustness and decrease in network response ability during the aging process: a systems

Chien-Ta Tu1, Bor-Sen Chen

  • 1Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, No 101, Section 2, Kuang-Gu Road, Hsinchu, Taiwan 30013, ROC.

IEEE/ACM Transactions on Computational Biology and Bioinformatics
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

Aging gene networks become more robust but less responsive with age. Key genes like FOXOs, NF-κB, and p53 show altered responses in older individuals, impacting health and disease resistance.

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Published on: October 19, 2021

Area of Science:

  • Gerontology and Systems Biology
  • Investigating the complex biological processes of aging at a systems level.

Background:

  • Aging is a complex process linked to chronic diseases in the elderly.
  • Gene mutations and environmental factors contribute to aging-related cellular changes.
  • Understanding gene network dynamics during aging is crucial for medical research.

Purpose of the Study:

  • To develop novel methods for analyzing gene network robustness and response ability during aging.
  • To gain insights into the systematic changes occurring in gene regulatory networks with age.
  • To identify age-related differences in gene network behavior and their implications.

Main Methods:

  • Proposed novel methods to estimate network robustness and measure network response ability.
  • Utilized microarray data from aging processes to analyze gene regulatory networks.
  • Compared network properties between young and aged subjects.

Main Results:

  • Aging gene networks exhibit increased robustness to intrinsic perturbations in the elderly compared to the young.
  • Older individuals show decreased responsiveness of gene networks to external stimuli.
  • Significant differences in the response abilities of individual genes (e.g., FOXOs, NF-κB, p53) were observed between young and aged subjects.

Conclusions:

  • The findings suggest a trade-off between robustness and responsiveness in aging gene networks.
  • Altered gene responses in the aged are consistent with increased tumorigenesis and reduced stress resistance.
  • The proposed methods can aid in analyzing dynamic biological processes and identifying drug targets.