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Updated: May 9, 2026
Use of Autometallography to Localize and Semi-Quantify Silver in Cetacean Tissues
Published on: October 4, 2018
The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials
Tolulope A Aweda1, Oluwatayo Ikotun, Tara Mastren
1Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 S. Kingshighway Blvd, St. Louis, MO 63110. ; Tel: 314-362-0284; Tel: 314-367-5537; Tel: 314-362-8154.
Abstract:
Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.
