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Lichen planopilaris: update on pathogenesis and treatment
Akerke Baibergenova1, Jeff Donovan
1Division of Dermatology, University of Toronto Sunnybrook Health Sciences Centre, Toronto, ON, Canada. akerke_b@yahoo.com
Skinmed
|August 13, 2013
Summary
Lichen planopilaris (LPP) causes scarring alopecia by destroying hair follicles. Treatments aim to reduce symptoms and stop hair loss, but management can be challenging.
Area of Science:
- Dermatology
- Pathology
Background:
- Lichen planopilaris (LPP) is a follicular variant of lichen planus.
- It leads to cicatricial alopecia due to irreversible hair follicle stem cell destruction.
- Clinical variants include classic LPP, frontal fibrosing alopecia, and Graham-Little-Piccardi-Lassueur syndrome.
Purpose of the Study:
- To summarize the understanding of LPP pathogenesis, clinical presentation, diagnosis, and management.
- To highlight treatment strategies and challenges in managing LPP.
Main Methods:
- Review of clinical and pathological features of LPP.
- Summary of current treatment modalities for LPP.
Main Results:
- Early LPP symptoms include scalp pruritus, burning, tenderness, and hair shedding.
- Scalp biopsy reveals lymphocytic infiltrate, apoptotic cells, and concentric fibrosis.
- Treatment involves topical/intralesional corticosteroids, systemic anti-inflammatories, or immunosuppressants.
Conclusions:
- LPP management requires a multi-faceted approach to alleviate symptoms and prevent further hair loss.
- Hair transplantation may be considered in stable cases.
- Further research is needed to improve LPP treatment outcomes.
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