Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephrolithiasis and bone involvement in primary hyperparathyroidism.

S J Silverberg1, E Shane, T P Jacobs

  • 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.

The American Journal of Medicine
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

The clinician's guide to prevention and treatment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Revisiting the endocrine and metabolic manifestations of COVID-19 two years into the pandemic.

Reviews in endocrine & metabolic disorders·2022
Same author

In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

A Simple Formula to Estimate Parathyroid Weight on 4D-CT, Predict Pathologic Weight, and Diagnose Parathyroid Adenoma in Patients with Primary Hyperparathyroidism.

AJNR. American journal of neuroradiology·2020
Same author

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same journal

Mineralocorticoid Antagonists for Post-MI HFpEF: Plausible Biology Meets Low Residual Risk?

The American journal of medicine·2026
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric panniculitis.

The American journal of medicine·2026
See all related articles

Primary hyperparathyroidism patients with and without kidney stones show similar bone density and biochemical profiles. However, increased urinary hydroxyproline in stone-formers suggests shared pathophysiologic pathways in renal and skeletal involvement.

Area of Science:

  • Endocrinology
  • Nephrology
  • Bone Metabolism

Background:

  • Primary hyperparathyroidism (PHPT) is a condition characterized by elevated parathyroid hormone levels.
  • Nephrolithiasis (kidney stones) and bone involvement are common complications of PHPT.
  • The relationship between renal and skeletal manifestations in PHPT requires further elucidation.

Purpose of the Study:

  • To compare biochemical profiles and bone involvement in PHPT patients with and without nephrolithiasis.
  • To investigate potential shared pathophysiologic mechanisms between renal and skeletal complications in PHPT.

Main Methods:

  • A cohort of 62 PHPT patients with mild hypercalcemia and elevated parathyroid hormone underwent bone densitometry.
  • Bone mineral density was assessed using dual-photon and single-photon absorptiometry.

Related Experiment Videos

  • Biochemical parameters, including serum calcium, phosphorus, vitamin D metabolites, and urinary calcium and hydroxyproline excretion, were analyzed.

    • Main Results:

    • No significant differences in serum parathyroid hormone, calcium, phosphorus, or vitamin D levels were observed between patients with and without nephrolithiasis.
    • Patients with nephrolithiasis exhibited higher total daily urinary calcium excretion and urinary hydroxyproline levels.
    • Bone mineral density at the forearm, femoral neck, and lumbar spine was comparable between the two groups, despite significant cortical bone demineralization in 61% of the cohort.

    Conclusions:

    • Cortical bone demineralization occurs with similar frequency and extent in PHPT patients, irrespective of nephrolithiasis.
    • Biochemical and bone densitometric profiles are largely similar between PHPT patients with and without kidney stones.
    • Increased urinary hydroxyproline in stone-formers suggests that renal and skeletal involvement in PHPT may share less selective pathophysiologic pathways than previously thought.