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Cutaneous adnexal carcinomas with divergent differentiation
R E Nakhleh1, P E Swanson, M R Wick
1Department of Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis.
The American Journal of Dermatopathology
|August 1, 1990
Summary
Mixed cutaneous adnexal carcinomas are rare skin tumors with diverse histologic patterns. These neoplasms show limited aggressive potential and are recognizable entities with immunohistochemical support.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Adnexal carcinomas of the skin are uncommon and present with varied histologic features.
- These tumors can exhibit differentiation from multiple appendageal structures.
Purpose of the Study:
- To characterize mixed cutaneous adnexal carcinomas.
- To evaluate their clinical behavior and immunohistochemical profiles.
Main Methods:
- Histologic examination of seven mixed adnexal carcinomas.
- Immunohistochemical analysis for keratin, epithelial membrane antigen, carcinoembryonic antigen, amylase, vimentin, S100 protein, and gross cystic disease fluid protein-15.
- Clinical follow-up data collection.
Main Results:
- Seven cases identified with combined pilar, sebaceous, and/or sudoriferous differentiation.
- Tumors located on the head and neck in patients aged 21-84.
- Six of seven patients showed no disease recurrence after 1 year post-excision.
- Immunohistochemistry revealed consistent keratin and epithelial membrane antigen expression; variable expression of carcinoembryonic antigen and amylase; negative for vimentin, S100 protein, and GCDFP-15.
Conclusions:
- Mixed cutaneous adnexal carcinomas are distinct entities.
- These tumors generally exhibit a low potential for aggressive growth.
- Immunohistochemistry aids in defining the cellular origins of these neoplasms.