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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: May 9, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Predictors of changes in suicidality in multiple sclerosis over time.

Sara Flood1, Frederick W Foley, Vance Zemon

  • 1Ferkauf Graduate School of Psychology , Bronx, NY , USA .

Disability and Rehabilitation
|August 13, 2013
PubMed
Summary

Depression significantly impacts suicidality in multiple sclerosis (MS) patients over time. Monitoring depression is crucial for reducing suicide risk in individuals with MS.

Keywords:
Depressionmultiple sclerosissuicide

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Published on: June 30, 2014

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Last Updated: May 9, 2026

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10:46

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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

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Published on: June 30, 2014

Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Suicidality rates are elevated in individuals with multiple sclerosis (MS) compared to the general population.
  • Understanding the temporal consistency of suicidality in MS is critical for effective mental health interventions.

Purpose of the Study:

  • To evaluate the consistency of suicidality over time in patients diagnosed with multiple sclerosis.
  • To identify predictors of suicidality in MS patients, focusing on depression and disability.

Main Methods:

  • Longitudinal data from 344 outpatients with MS at a large medical center were analyzed.
  • Binary logistic regression was employed to assess the influence of gender, age, depression, and disability on suicidality.
  • Suicidality levels were examined at two distinct time points (Time 1 and Time 2).

Main Results:

  • Baseline depression and changes in depression levels significantly predicted suicidality at Time 2.
  • Demographic variables, baseline disability, and changes in disability did not significantly predict suicidality.
  • The interaction between changes in depression and disability over time did not influence suicidality levels.

Conclusions:

  • Interventions focused on evaluating and monitoring depression are recommended to mitigate suicide risk in MS patients.
  • Routine depression assessment is vital due to the unpredictable nature of MS and its high comorbidity with depression and suicidality.
  • Healthcare providers should encourage and ensure access to mental health services for individuals with MS.