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Related Concept Videos

Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.

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Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Blood flow vectoring control in aortic arch using full and partial clamps.

Seyed Roholah Ghodsi1, Vahid Esfahanian, Rahim Shamsodini

  • 1VFE Research Institute, University of Tehran, Tehran, Iran. dr.sr.ghodsi@ut.ac.ir

Computers in Biology and Medicine
|August 13, 2013
PubMed
Summary

Controlling blood flow with a partial clamp, a method called Blood Flow Vectoring Control (BFVC), can alter streamlines and reduce stress concentration, potentially preventing aneurysm growth.

Keywords:
AneurysmAortaBlood flowComputersStress

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Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine
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Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine

Published on: August 24, 2018

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Computational Mechanics

Background:

  • Aneurysms pose a significant mortality risk, influenced by factors like arteriosclerosis, heredity, pressure, and Wall Shear Stress (WSS).
  • Early diagnosis and treatment are crucial for reducing rupture-related mortality.
  • Understanding factors influencing aneurysm development is key to prevention.

Purpose of the Study:

  • To investigate the efficacy of partial or full aortic arch clamping in controlling blood flow streamlines.
  • To determine how clamp characteristics influence stress concentration locations.
  • To explore methods for reducing aneurysm growth potential by managing stress distributions.

Main Methods:

  • Simulated blood flow in a simplified aortic arch model using computational fluid dynamics (CFD).
  • Employed the Shear Stress Transport model for steady-state Newtonian blood flow at a Reynolds number of approximately 6500.
  • Conducted a parameter study on clamp size, location, and coverage percentage.

Main Results:

  • Clamp location was found to be more influential than clamp size in altering flow streamlines.
  • Increasing clamp depth negatively impacted mean velocity and increased stress concentration.
  • Blood Flow Vectoring Control (BFVC) effectively modified flow streamlines and WSS distributions.

Conclusions:

  • Blood Flow Vectoring Control (BFVC) can effectively alter flow streamlines, pressure, and Wall Shear Stress (WSS) distributions.
  • Partial clamping demonstrated superior results compared to full clamping for managing stress concentrations.
  • BFVC offers a potential strategy for mitigating aneurysm growth by optimizing hemodynamic forces.