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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Frequency of diabetic cardiomyopathy among type-2 diabetics presenting as heart failure
1Department of Cardiology, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan. zilmohammad@hotmail.com
Insights
Diabetic cardiomyopathy is a common cause of heart failure in patients with type-2 diabetes, affecting 40% of those studied. This condition leads to significant morbidity and mortality, highlighting the need for early detection and management.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Type-2 diabetes mellitus is a growing global health concern.
- Overt heart failure in diabetic patients often presents complex etiological factors.
- Diabetic cardiomyopathy is an under-recognized complication of diabetes.
Purpose of the Study:
- To ascertain the prevalence of diabetic cardiomyopathy in patients with type-2 diabetes and overt heart failure.
- To investigate the clinical characteristics and outcomes of heart failure in this population.
Main Methods:
- A case series study was conducted involving 100 patients with type-2 diabetes and heart failure symptoms.
- Comprehensive investigations included laboratory tests, electrocardiography, echocardiography, and coronary angiography.
- Data were collected over a 15-month period at a tertiary care hospital.
Main Results:
- Diabetic cardiomyopathy was diagnosed in 40% of the study cohort.
- A significant proportion (40%) exhibited marked left ventricular systolic dysfunction (ejection fraction < 30%).
- Hospitalization resulted in mortality for 5% of patients.
Conclusions:
- Diabetic cardiomyopathy is a prevalent cause of heart failure among individuals with type-2 diabetes.
- The condition is associated with substantial morbidity and mortality.
- Findings underscore the importance of screening for diabetic cardiomyopathy in diabetic patients with heart failure.
Objective:
To determine the frequency of diabetic cardiomyopathy among patients with type-2 diabetes presenting with overt heart failure.
Study Design:
Case series.
Place And Duration Of Study:
Department of Cardiology, Mayo Hospital, Lahore, from April 2008 to July 2009.
Methodology:
One hundred patients with type-2 diabetes mellitus having symptoms and signs of heart failure were enrolled. Anthropometric parameters were recorded and all patients had investigations including complete blood count, blood glucose (fasting and random), serum creatinine, fasting lipid profile, haemoglobin A1c, chest X-ray, electrocardiogram and Doppler echocardiography. After stabilization, every patient underwent coronary angiography. The data was entered in a structured proforma.
Results:
Sixty (60%) patients were males and 40 (40%) were females. Duration of diabetes was > 10 years in all. Eighty (80%) were on oral hypoglycemic and 20 (20%) were on insulin. Diabetic cardiomyopathy was found in 40 patients (40%) of the total study patients. Forty percent (40%) patients had marked left ventricular (LV) systolic dysfunction (ejection fraction < 30%). Three (5%) patients died during hospitalization.
Conclusion:
Diabetic cardiomyopathy is a fairly common cause of heart failure in the native population with type-2 diabetes mellitus and results in high morbidity and mortality.
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