Intraoperative nodal staging: role of sentinel node technology

In cases of superficial malignancies such as melanoma or breast cancer, intraoperative lymph node mapping with a sentinel lymph node (SLN) biopsy is an effective and minimally invasive alternative to inguinal or axillary lymph node dissection for early-stage tumors. For primary lung cancer, although much effort has been made to investigate a variety of tracers, such as dyes, radioisotopes, magnetite, and iopamidol, for discerning SLNs, an appropriate agent that produces high identification and accuracy rates has yet to be developed. Further studies are needed to find an ideal tracer for practical use in patients with non-small cell lung cancer.