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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

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Published on: December 9, 2015

Biologic approaches to drug selection and targeted therapy: hype or clinical reality?

Dennis A Wigle1

  • 1Thoracic Surgery, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA. wigle.dennis@mayo.edu

Thoracic Surgery Clinics
|August 13, 2013
PubMed

Insights

Genomic-driven oncology tailors cancer care by targeting specific genetic alterations. For non-small cell lung cancer, new targeted therapies and biomarkers are improving patient treatment strategies.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Cancer is a genetic disease driven by oncogene and tumor suppressor alterations.
  • Individualized treatment approaches leverage genomic information for cancer care.

Purpose of the Study:

  • To review key advances in targeted therapies and biomarkers for non-small cell lung cancer.
  • To provide commentary and perspective for thoracic surgical oncologists.

Main Methods:

  • Review of recent scientific literature and clinical advancements.
  • Analysis of novel targeted agents and biomarkers in oncology.

Main Results:

  • The landscape of non-small cell lung cancer management is evolving.
  • An increasing number of targeted agents and biomarkers are impacting patient care.

Conclusions:

  • Genomics-driven approaches are central to modern oncology.
  • Advances in targeted therapies and biomarkers are transforming non-small cell lung cancer treatment.
Keywords:
ALK translocationEGFR mutationIndividualized medicineTargeted therapyTumor genome sequencing

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