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Updated: May 9, 2026
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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Reconsidering remineralization strategies to include nanoparticle hydroxyapatite.
V Kim Kutsch1, Yada Chaiyabutr, Graeme Milicich
1Oral Biotech, Albany, Oregon, USA.
Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995)
|August 13, 2013
Summary
This study shows nanoparticle hydroxyapatite can remineralize demineralized tooth enamel. This offers a new approach to prevent and treat dental caries by restoring tooth mineral content.
Area of Science:
- Biomaterials Science
- Dental Research
- Cariology
Background:
- Dental caries is a biofilm-mediated disease causing tooth demineralization due to prolonged low pH.
- Tooth minerals like hydroxyapatite are lost, leading to lesions and cavitation.
- Current remineralization strategies primarily use fluoride and calcium phosphate, but new approaches are needed.
Purpose of the Study:
- To investigate the efficacy of nanoparticle hydroxyapatite in remineralizing demineralized enamel.
- To explore the potential of pH neutralization combined with nanoparticle hydroxyapatite for dental hard tissue repair.
Main Methods:
- An in-vitro study design was employed.
- Demineralized enamel surfaces were treated with an experimental remineralization gel containing nanoparticle hydroxyapatite.
- Deposition of nanoparticle hydroxyapatite on enamel was analyzed.
Main Results:
- The experimental gel successfully deposited nanoparticle hydroxyapatite onto demineralized enamel surfaces.
- Evidence of remineralization was observed following the treatment.
Conclusions:
- Nanoparticle hydroxyapatite shows promise as a remineralizing agent for dental hard tissues.
- Combining pH neutralization with nanoparticle hydroxyapatite presents a novel strategy for managing dental caries.
