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Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils

Tania Sheynis1, Anat Friediger, Wei-Feng Xue

  • 1Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Biophysical Journal
|August 13, 2013
PubMed
Summary

Certain compounds like epigallocatechin gallate and heparin can prevent amyloid fibril damage to cell membranes. This finding offers new therapeutic strategies for amyloid diseases beyond targeting protein self-assembly.

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