Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasmalogen deficiency and the Alzheimer's disease risk of apolipoprotein E4.

Brain communications·2026
Same author

Stroke in Fabry Disease: Identification of Risk Factors for Stroke in a Large Single-Centre Cohort.

European journal of neurology·2025
Same author

Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a UK national cohort.

Brain communications·2023
Same author

Acute and chronic neuropathies.

Medicine (Abingdon, England : UK ed.)·2020
Same author

Vasculitis and the peripheral nervous system.

Rheumatology (Oxford, England)·2020
Same author

Adolescent Interventions to Manage Self-Regulation in Type 1 Diabetes (AIMS-T1D): randomized control trial study protocol.

BMC pediatrics·2020

Related Experiment Video

Updated: May 9, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

The nerve biopsy: indications, technical aspects, and contribution.

Rosalind King1, Lionel Ginsberg

  • 1Department of Clinical Neurosciences, Institute of Neurology, University College London, Royal Free Campus, London, UK.

Handbook of Clinical Neurology
|August 13, 2013
PubMed
Summary

Peripheral nerve biopsy is a valuable diagnostic tool for neuropathy. This guide details indications, surgical procedures, and interpretation of results to ensure accurate diagnosis and avoid errors.

Keywords:
diagnosiselectron microscopyimmunohistochemistrynerve biopsyneuropathysural nervetechniques

More Related Videos

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
10:25

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones

Published on: January 26, 2012

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
05:18

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation

Published on: September 27, 2020

Related Experiment Videos

Last Updated: May 9, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
10:25

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones

Published on: January 26, 2012

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
05:18

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation

Published on: September 27, 2020

Area of Science:

  • Neurology
  • Pathology
  • Surgical Science

Background:

  • Peripheral neuropathies are diverse, necessitating accurate diagnostic methods.
  • Nerve biopsy offers direct tissue examination for etiological diagnosis.

Purpose of the Study:

  • To provide comprehensive guidance on peripheral nerve biopsy.
  • To detail indications, surgical techniques, and diagnostic interpretation.

Main Methods:

  • Discussion of biopsy indications and nerve selection criteria.
  • Description of surgical procedures, aftercare, and potential complications.
  • Detailed explanation of nerve processing, staining, and microscopy techniques (light and electron).

Main Results:

  • Summarizes causes of neuropathy and biopsy utility.
  • Highlights methods for assessing fiber density, size, and myelin thickness.
  • Illustrates key diagnostic features and common interpretation pitfalls.

Conclusions:

  • Peripheral nerve biopsy is a crucial procedure for diagnosing neuropathies.
  • Proper technique and interpretation are vital to avoid diagnostic errors.
  • This chapter serves as a comprehensive resource for clinicians and pathologists.