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Related Experiment Video

Updated: May 9, 2026

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

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Chronic inflammatory demyelinative polyneuropathy.

Gérard Said¹, Christian Krarup

¹Department of Neurology, Hôpital de la Salpêtrière, Paris, France.

Handbook of Clinical Neurology

|August 13, 2013

Summary

This summary is machine-generated.

Chronic inflammatory demyelinative polyneuropathy (CIDP) is an autoimmune disorder causing progressive motor deficits. Diagnosis requires specific clinical and nerve conduction findings, and early treatment improves outcomes.

Keywords:

CIDP POEMS demyelinative neuropathies diabetes nerve biopsy nerve conduction treatment

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Last Updated: May 9, 2026

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Published on: May 11, 2022

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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

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Published on: November 9, 2017

Area of Science:

Neurology
Immunology
Clinical Medicine

Background:

Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired autoimmune disorder.
It typically presents with progressive or relapsing motor deficits.

Purpose of the Study:

To outline the diagnostic criteria for CIDP.
To discuss the prognostic factors and differential diagnoses.
To review initial treatment options for CIDP.

Main Methods:

Diagnosis relies on clinical presentation (non-length-dependent, predominantly motor deficit, progressive/relapsing course).
Requires elevated cerebrospinal fluid (CSF) protein content.
Nerve conduction studies demonstrating asymmetrical demyelinating features are essential.

Main Results:

Outcome is influenced by the degree of axon loss alongside demyelination.
CIDP must be distinguished from neuropathies linked to monoclonal gammopathies.

Conclusions:

CIDP is an immune-mediated polyneuropathy with characteristic clinical and electrodiagnostic findings.
Effective initial treatments include corticosteroids, IVIg, and plasma exchange.