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Related Experiment Video

Updated: May 9, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

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Published on: February 13, 2018

Vasculitic neuropathy.

Alexander F J E Vrancken1, Gérard Said

  • 1Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands.

Handbook of Clinical Neurology
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

Vasculitis, an autoimmune condition, can cause nerve damage by affecting small arteries. Treatment involves corticosteroids and immunosuppressants to manage inflammation and prevent further nerve injury.

Keywords:
mononeuritis multiplexmononeuropathy multiplexperipheral neuropathyvasculitic neuropathyvasculitis

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Last Updated: May 9, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Area of Science:

  • Neurology
  • Immunology
  • Rheumatology

Background:

  • Vasculitis is a key feature of various autoimmune diseases.
  • It can also arise secondarily in conditions like infections or diabetes.
  • Vasculitic neuropathy results from damage and blockage of small nerve arteries.

Purpose of the Study:

  • To describe vasculitic neuropathy.
  • To highlight its causes and presentation.
  • To outline treatment strategies.

Main Methods:

  • Review of vasculitis and its neurological complications.
  • Analysis of disease mechanisms in vasculitic neuropathy.
  • Examination of treatment protocols.

Main Results:

  • Vasculitis affects small epineurial arteries, leading to neuropathy.
  • Nonsystemic vasculitic neuropathy is limited to nerves and muscles.
  • Inflammation causes vessel wall destruction and lumen occlusion.

Conclusions:

  • Vasculitic neuropathy requires prompt treatment.
  • Corticosteroids and immunosuppressants are crucial.
  • Effective management prevents further ischemic nerve damage.