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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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Related Experiment Video

Updated: May 9, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Leprous neuropathy.

Marcos R G de Freitas1, Gérard Said

  • 1Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, Brazil.

Handbook of Clinical Neurology
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

Leprous neuropathy, caused by Mycobacterium leprae, leads to nerve damage and disability, especially when not detected early. Treatment involves multidrug therapy, with corticosteroids aiding in managing nerve damage during reactions.

Keywords:
Mycobacterium lepraeleprosyleprous neuropathynerve biopsypure neural leprosy

More Related Videos

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Related Experiment Videos

Last Updated: May 9, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Leprous neuropathy, a complication of Mycobacterium leprae infection, causes significant disability globally.
  • Host resistance influences the clinical presentation and pathology of leprosy.
  • Delayed diagnosis of leprosy often results in irreversible nerve damage.

Purpose of the Study:

  • To summarize the pathogenesis, clinical manifestations, and treatment of leprous neuropathy.
  • To highlight the diagnostic challenges and management strategies for nerve damage in leprosy.

Main Methods:

  • Review of literature on leprous neuropathy.
  • Analysis of clinical and pathological features of different leprosy types.
  • Discussion of current treatment protocols and management of complications.

Main Results:

  • Leprosy affects nerve cells, with manifestations varying based on host immunity.
  • Lepromatous leprosy can present with symmetrical neuropathy or pure neuritic forms; tuberculoid leprosy often shows a multifocal pattern.
  • Reversal reactions in multibacillary leprosy can exacerbate nerve damage, necessitating corticosteroid use.

Conclusions:

  • Early detection and treatment are crucial to prevent disability from leprous neuropathy.
  • Multidrug therapy is the standard treatment, supplemented by corticosteroids for managing reactions and preventing nerve damage.
  • Sensory loss is a common sequela, leading to secondary injuries in anesthetic areas.