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Updated: May 9, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Paraneoplastic neuropathy.

Haruki Koike¹, Gen Sobue

¹Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Handbook of Clinical Neurology

|August 13, 2013

Summary

This summary is machine-generated.

Paraneoplastic neurological syndromes, often involving the peripheral nervous system, are increasingly recognized with new diagnostic tools. Early diagnosis of paraneoplastic neuropathy is crucial for better patient outcomes.

Keywords:

Guillain–Barré syndrome autonomic neuropathy chronic inflammatory demyelinating polyneuropathy chronic intestinal pseudo-obstruction neuropathy paraneoplastic neuropathy paraneoplastic syndrome sensory neuronopathy vasculitic neuropathy vasculitis

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

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Published on: April 26, 2012

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Area of Science:

Neurology
Oncology
Immunology

Background:

Paraneoplastic neurological syndromes (PNS) are expanding beyond classic definitions.
Peripheral nervous system involvement is common in PNS, presenting diverse clinical features.
Advances in serological screening and imaging aid in identifying malignancies associated with neurological symptoms.

Purpose of the Study:

To review the current understanding of paraneoplastic neuropathy.
To highlight the diverse clinical manifestations and associated antibodies.
To emphasize the importance of early diagnosis and treatment for improved outcomes.

Main Methods:

Review of recent advancements in diagnostic techniques for PNS.
Analysis of serological screening for paraneoplastic antibodies.
Integration of clinical features with imaging findings.

Main Results:

Peripheral neuropathies, including sensory neuronopathy, Guillain-Barré syndrome-like presentations, and autonomic neuropathies, are frequent in PNS.
Specific onconeural antibodies (e.g., anti-Hu, anti-CV2/CRMP-5, anti-ganglionic acetylcholine receptor) are linked to distinct neuropathy types.
Whole-body fluorodeoxyglucose positron emission tomography (FDG-PET) can detect occult malignancies.

Conclusions:

Paraneoplastic neuropathy encompasses a wide spectrum of conditions affecting the peripheral nervous system.
Timely diagnosis, aided by antibody detection and advanced imaging, is critical as symptoms often precede tumor identification.
Early intervention in paraneoplastic neuropathy offers a better prognosis.