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Elevated serum ApoE levels are associated with bacterial infections in pediatric patients

Pan Fu1, Ai-Min Wang1, Lei-Yan He1

  • 1Clinical Microbiology Laboratory, Department of Nosocomial Infection Control, Children's Hospital of Fudan University, Shanghai 201102, China.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|August 13, 2013
PubMed

Insights

Serum apolipoprotein E (ApoE) is elevated in children with bacterial infections like sepsis. Reduced expression of ApoE receptors in mice suggests impaired clearance contributes to higher blood levels, potentially aiding bacterial infection diagnosis.

Area of Science:

  • Pediatric Infectious Diseases
  • Biochemistry
  • Immunology

Background:

  • Apolipoprotein E (ApoE) plays a role in lipid metabolism and immune response.
  • Variations in ApoE levels can indicate underlying health conditions.

Purpose of the Study:

  • To determine serum ApoE level variations in pediatric patients with diverse infections.
  • To investigate the mechanism behind elevated ApoE during infection.

Main Methods:

  • Serum ApoE levels measured via immunoturbidimetric assay in 279 pediatric patients and 58 controls.
  • Mouse sepsis model used to assess ApoE and receptor expression via RT-PCR and Western blotting.

Main Results:

  • Markedly increased serum ApoE observed in bacterial infections (sepsis, meningitis, pneumonia).
  • No significant elevation in aseptic meningitis or Mycoplasma pneumonia.
  • Mouse models showed increased serum ApoE and reduced hepatic expression of ApoE and its receptors (LDLR, LRP, SDC1) during sepsis.

Conclusions:

  • Serum ApoE may serve as a novel diagnostic indicator for pediatric bacterial infections, particularly sepsis.
  • Decreased expression of LDLR, LRP, and SDC1 may impair ApoE clearance, leading to blood accumulation.
Abstract

Keywords:
Apolipoprotein EHeparan sulfate proteoglycan (HSPG)LDL receptor-related protein (LRP)Low-density lipoprotein receptor (LDLR)SepsisSyndecan-1 (SDC1)

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