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Related Concept Videos

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
Proton (¹H) NMR: Chemical Shift01:07

Proton (¹H) NMR: Chemical Shift

Organic molecules primarily contain carbon and hydrogen atoms. While all the hydrogen isotopes are NMR-active, protium or hydrogen-1 is the most abundant. It has a significant energy separation between its nuclear spin states due to its large gyromagnetic ratio. As per Boltzmann's distribution, an increase in the energy separation implies a greater excess population of nuclei available for excitation, resulting in a strong NMR absorption signal.
Absorption signals of all the protium nuclei in a...
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.
¹H NMR of Labile Protons: Deuterium (²H) Substitution00:48

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This lesson illustrates the role of deuterium substitution in simplifying the NMR spectrum of compounds comprising labile protons. One method employed is the use of deuterium. Amongst the three isotopes of hydrogen, deuterium (2H) has a nucleus composed of one proton and one neutron. When the D2O solvent is added to a pure dry ethanol solution, its labile proton is substituted with deuterium.
2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
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Hyperpolarized Xenon for NMR and MRI Applications
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Para-hydrogen perspectives in hyperpolarized NMR.

Stefan Glöggler1, Johannes Colell, Stephan Appelt

  • 1Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Young Hall 2056, Los Angeles, CA 90095, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|August 13, 2013
PubMed
Summary

Para-hydrogen induced polarization (PHIP) enhances NMR signals. Recent advances allow signal amplification without altering molecular structures, expanding hyperpolarized compound applications.

Keywords:
ALTADENAAtomic magnetometersCatalysisEarth fieldGas phase imagingHyperpolarizationImmobilized catalystsInhomogeneous fieldsLong-lived coherencesLow magnetic fieldsMRI contrastMetabolic imagingMolecular imagingNMR spectroscopyNanoparticlesPASADENAPHIPPara-hydrogenReaction monitoringRemote detectionSABRESinglet statesTrace detectionZero-field

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Hyperpolarization Techniques
  • Quantum Chemistry

Background:

  • Para-hydrogen induced polarization (PHIP) was first observed serendipitously in NMR experiments during the 1980s.
  • Theoretical investigations in the 1980s established the foundational principles of the PHIP effect.
  • Recent discoveries in signal amplification via non-hydrogenating interactions with para-hydrogen have renewed interest in PHIP.

Purpose of the Study:

  • To emphasize the future applications of para-hydrogen induced polarization (PHIP).
  • To provide a brief overview of the historical development and understanding of the PHIP phenomenon.
  • To explore the advantages of using hyperpolarized compounds in spectroscopy.

Main Methods:

  • Review of historical NMR experiments and theoretical studies on PHIP.
  • Discussion of recent advancements in PHIP, including non-hydrogenating interactions.
  • Focus on the principles enabling signal amplification and hyperpolarization.

Main Results:

  • PHIP was initially discovered serendipitously during hydrogenation reactions.
  • Theoretical work provided a basis for understanding the PHIP effect.
  • New methods allow signal amplification without structural alteration of compounds.

Conclusions:

  • The PHIP effect offers significant potential for future applications in NMR spectroscopy.
  • Hyperpolarization via PHIP enables the study of compounds with enhanced sensitivity.
  • Continued research into PHIP promises broader applications in chemical and biological investigations.