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Related Experiment Video

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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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An annulus fibrosus closure device based on a biodegradable shape-memory polymer network.

Shahriar Sharifi1, Theo G van Kooten, Hendrik-Jan C Kranenburg

  • 1University of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, W.J. Kolff Institute, PO Box 196, 9700 AD Groningen, The Netherlands.

Biomaterials
|August 13, 2013
PubMed
Summary

Biodegradable shape-memory polymer networks show promise for closing tears in the annulus fibrosus (AF), potentially alleviating lower back pain. These materials support cell growth and can be implanted minimally invasively.

Keywords:
Annulus fibrosusIntervertebral diskPhoto-crosslinkingShape-memoryThermo-mechanical analysisd,l-lactide and trimethylene carbonate-based networks

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Intervertebral disc injuries, including annulus fibrosus (AF) tears, are a common cause of lower back pain.
  • Current treatments often involve invasive procedures or lack effective tissue regeneration strategies.

Purpose of the Study:

  • To evaluate poly(D,L-lactide-co-trimethylene carbonate) networks with shape-memory properties for biodegradable AF closure devices.
  • To assess the mechanical, shape-memory, and cellular compatibility of these novel polymer networks.

Main Methods:

  • Synthesis of four poly(D,L-lactide-co-trimethylene carbonate) macromers with varying DLLA:TMC ratios via photo-crosslinking.
  • Characterization of mechanical and shape-memory properties using tensile and cyclic thermo-mechanical tests.
  • In vitro evaluation of human AF cell adhesion, growth, and extracellular matrix production on polymer films, with and without fibronectin coating.

Main Results:

  • All networks exhibited rubber-like behavior at 40°C with elastic moduli comparable to native AF tissue.
  • Excellent shape-memory properties were observed, with shape-fixity and shape-recovery ratios exceeding 98% and 95%, respectively.
  • The DLLA:TMC 60:40 ratio demonstrated superior support for human AF cell adhesion and growth, further enhanced by fibronectin coating.

Conclusions:

  • Biodegradable, shape-memory poly(D,L-lactide-co-trimethylene carbonate) networks are suitable for developing minimally invasive AF closure devices.
  • These materials exhibit favorable mechanical properties, excellent shape-memory characteristics, and promote AF cell integration.
  • The developed devices show potential for self-deployment after minimally invasive implantation in spinal discs.