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Optical Clearing and Imaging of Immunolabeled Kidney Tissue
06:18

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study

Ghada El Sayed Esheba1, Noha El Sayed Esheba

  • 1Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt. ghadaesheba@yahoo.com

Journal of the Egyptian National Cancer Institute
|August 13, 2013
PubMed
Abstract

Insights

Angiomyolipoma (AML) is a common kidney neoplasm, primarily affecting females. Diagnosis relies on characteristic clinicopathological and immunohistochemical features, with HMB-45 being a key marker.

Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Background:

  • Angiomyolipoma (AML) is the most frequent benign mesenchymal neoplasm of the kidney.
  • Despite its rarity, understanding AML is crucial for accurate diagnosis.

Purpose of the Study:

  • To detail the clinicopathological characteristics of renal angiomyolipoma.
  • To evaluate the diagnostic utility of immunohistochemical markers including HMB-45, Melan-A, SMA, S-100, and cytokeratin.

Main Methods:

  • Retrospective analysis of 15 angiomyolipoma cases.
  • Histopathological evaluation and immunohistochemical staining for HMB-45, Melan-A, SMA, S-100, and cytokeratin.

Main Results:

  • AML predominantly affects females (4:1 ratio) with a mean age of 53.9 years.
  • Tumor size correlates with symptoms (P=0.02); larger tumors (>4 cm) are symptomatic.
  • HMB-45 was positive in 100% of cases, Melan-A in 87%, and SMA in 73%. S-100 and cytokeratin were negative.

Conclusions:

  • Renal angiomyolipomas exhibit distinct clinicopathological and immunohistochemical profiles.
  • Accurate recognition of these features is essential for appropriate patient management and treatment.
Keywords:
AMLAngiomyolipomaCTEAMLsHMB-45HPFHuman Melanoma BlackMRIMagnetic Resonance ImagingMelan-APECPEComasSMASmooth muscle actinTSCU/SWHOWorld Health Organizationangiomyolipomacomputed tomographyepithelioid angiomyolipomashigh power fieldpaperivascular epithelioid cellperivascular epithelioid cell tumorssmooth muscle actintuberous sclerosis complexultrasound

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