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A New Method for Inducing a Depression-Like Behavior in Rats

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Published on: February 22, 2018

Anxiety comorbidity in schizophrenia.

Raphael J Braga¹, Graham P Reynolds, Samuel G Siris

¹The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Department of Psychiatry Research, Glen Oaks, NY, USA; Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine at Hofstra University, Hempstead, NY, USA.

Psychiatry Research

|August 13, 2013

Summary

Anxiety disorders are common in schizophrenia, affecting over a third of patients. Addressing these comorbid conditions is crucial for improving clinical outcomes and patient well-being.

Keywords:

Anxiety Comorbidity Review Schizophrenia

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Area of Science:

Psychiatry
Clinical Psychology
Neuroscience

Background:

Hierarchical reductionist approaches in diagnosis and treatment have historically overlooked anxiety syndromes in schizophrenia.
Emerging evidence highlights anxiety as a significant contributor to morbidity in individuals with schizophrenia spectrum disorders.

Purpose of the Study:

To review the current understanding of anxiety comorbidity in schizophrenia, including its epidemiology, clinical course, and therapeutic strategies.
To synthesize existing literature on the prevalence, impact, and management of anxiety disorders in schizophrenia.

Main Methods:

A comprehensive computerized literature search was performed using the Medline database.
The search covered publications from 1966 to July 2012, focusing on anxiety comorbidity in schizophrenia spectrum disorders.

Main Results:

Comorbid anxiety disorders were identified in 38.3% of individuals with schizophrenia spectrum disorders.
Social phobia, post-traumatic stress disorder, and obsessive-compulsive disorder were the most frequently observed anxiety disorders.
The presence and severity of anxiety symptoms correlated with more severe clinical features and poorer patient outcomes.

Conclusions:

Anxiety disorders are a prevalent and significant comorbidity in schizophrenia, negatively impacting clinical presentation and prognosis.
Current treatment data are limited, primarily consisting of case reports and open trials, suggesting adjunctive medications and psychosocial interventions.
Further research is essential to establish definitive treatment guidelines for anxiety syndromes co-occurring with schizophrenia.