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Serum level of prostate-specific antigen (PSA) in women with breast cancer
Fawzi C Mashkoor1, Jasim N Al-Asadi, Lamia M Al-Naama
1Department of Biochemistry, College of Pharmacy, University of Basrah, Basrah, Iraq. fawzi_cm@yahoo.com
Objective:
To identify the diagnostic role of total and free prostate-specific antigen (TPSA and FPSA) in breast cancer in women.
Methods:
Blood samples of 55 women with breast cancer were prospectively analyzed for PSA before and after breast surgery, with a control group of 82 healthy women.
Results:
Total and free PSA levels were significantly higher in women with breast cancer (preoperatively) than in healthy women (P<0.001). Both serum TPSA and FPSA showed a significant decline in their pre-surgical values after surgical removal of the tumor (P<0.001). A significant proportion of breast cancer patients (83.6%) had free PSA as the predominant molecular form in serum as compared to 0% of controls and 1.8% of postoperative groups (P<0.001). TPSA and FPSA levels were significantly associated with younger age and earlier cancer stage, whereas no significant association was found between these two variables and FPSA as a predominant molecular form.
Conclusions:
This study indicated a clinical significance of preoperative measurement of serum TPSA and FPSA in the diagnosis of women with breast cancer, and may be a useful marker for monitoring the response to treatment.
