Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sulbactam-induced hyperpyrexia.

A H Olivencia-Yurvati1, S P Sanders

  • 1Department of Surgery, Tulsa Regional Medical Center, OK 74127.

Archives of Internal Medicine
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal echocardiographic assessment of right aortic arch.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2018
Same author

Bilorrhea secondary to bronchobiliary fistula.

International surgery·2014
Same author

Role of tricuspid regurgitation in fetal echocardiographic diagnosis of pulmonary atresia with intact ventricular septum.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2008
Same author

Severe Ebstein's anomaly can benefit from a small ventricular septal defect: two cases.

Pediatric cardiology·2007
Same author

Images in cardiovascular medicine. Two-dimensional and real-time three-dimensional echocardiographic fetal diagnosis of aorto-ventricular tunnel.

Circulation·2005
Same author

Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass.

Perfusion·2003
Same journal

Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

Archives of internal medicine·2017
Same journal

Occult Carbon Monoxide Poisoning-Reply.

Archives of internal medicine·2017
Same journal

Acquired Immune Deficiency Syndrome-Reply.

Archives of internal medicine·2017
Same journal

Heparin Side Effects-Reply.

Archives of internal medicine·2017
Same journal

Humanizing primary care medicine begins with stress.

Archives of internal medicine·2017
Same journal

Legend omitted and number misrepresented.

Archives of internal medicine·2013
See all related articles

A patient developed severe fever after receiving ampicillin-sulbactam, but not ampicillin alone. This suggests sulbactam may cause drug-induced hyperpyrexia, a previously unreported side effect.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Adverse Drug Reactions

Background:

  • Ampicillin-sulbactam is a commonly prescribed antibiotic combination.
  • Drug-induced hyperpyrexia is a rare but serious adverse event.
  • Identifying specific drug components responsible for adverse reactions is crucial for patient safety.

Observation:

  • A patient presented with unexplained hyperpyrexia (high fever) following administration of intravenous ampicillin-sulbactam sodium.
  • The hyperpyrexia did not occur when the patient received ampicillin alone in the past.
  • The fever could not be attributed to other concurrent medications, intravenous diluents, or a typical allergic response.

Findings:

  • The clinical presentation suggests a specific link between sulbactam and the development of hyperpyrexia.

Related Experiment Videos

  • This case highlights a previously unreported adverse effect potentially associated with the sulbactam component.
  • Exclusion of other causes strengthens the hypothesis implicating sulbactam in the pathogenesis.

    • Implications:

    • The sulbactam component of ampicillin-sulbactam should be considered as a potential cause of drug-induced hyperpyrexia.
    • Clinicians should be vigilant for this adverse reaction when prescribing this antibiotic combination.
    • Further investigation into the mechanism of sulbactam-induced hyperpyrexia is warranted.