Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026

Same author

Xaliproden improves diabetic kidney disease through JNK-mediated renal tubular protection.

Biochemical pharmacology·2026

Same author

Inhibition of CCL4 prevents renal inflammation and fibrosis in acute kidney injury.

Clinical science (London, England : 1979)·2026

Same author

Therapeutic potential of cytokine-induced killer cell therapy for renal cell carcinoma and prostate cancer.

Cell communication and signaling : CCS·2026

Same author

Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways.

Particle and fibre toxicology·2026

Same author

Optimizing Prostate Cancer Care: Clinical Utility of the Prostate Health Index.

The Prostate·2025

Search research articles

Related Experiment Video

Updated: May 9, 2026

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Induced pluripotent stem cells and hepatic differentiation.

Chih-Hung Chiang¹, Teh-Ia Huo, Cho-Chin Sun

¹Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, ROC; Division of Urology, Department of Surgery, Taipei Veterans General Hospital and Su-Ao/Yuan-Shan Branch, Yi-Lan, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA

|August 13, 2013

Summary

Induced pluripotent stem cells (iPSCs) offer a promising avenue for liver disease treatment. This review explores their potential in hepatic regeneration and clinical applications for liver repair.

Keywords:

hepatic repair induced pluripotent stem cells

More Related Videos

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Related Experiment Videos

Last Updated: May 9, 2026

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Efficient Differentiation of Human Pluripotent Stem Cells into Liver Cells

Published on: June 11, 2019

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

An Efficient Method for Directed Hepatocyte-Like Cell Induction from Human Embryonic Stem Cells

Published on: May 6, 2021

Area of Science:

Stem cell biology
Regenerative medicine
Hepatology

Background:

Induced pluripotent stem cells (iPSCs) are reprogrammed somatic cells with embryonic stem cell (ESC)-like properties.
iPSCs share characteristics with ESCs, including morphology, pluripotency markers, and teratoma formation potential.
These cells can differentiate into various lineages, including hepatic cells.

Purpose of the Study:

To review the therapeutic potential of iPSCs for hepatic repair.
To focus on the clinical applications of iPSCs in treating liver disease.

Main Methods:

Review of existing literature on iPSC generation and differentiation.
Analysis of studies investigating iPSC-based therapies for liver conditions.
Discussion of clinical trials and translational research.

Main Results:

iPSCs can be generated from diverse somatic cell types.
iPSCs demonstrate successful differentiation into functional hepatocytes.
Preclinical and clinical studies show promise for iPSC-based liver regeneration.

Conclusions:

iPSCs represent a viable cell source for hepatocyte regeneration.
iPSC-based therapies hold significant potential for treating liver diseases.
Further research and clinical application are warranted to fully realize iPSC therapeutic benefits.