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Panic disorder, comorbidity, and suicide attempts.

J Johnson1, M M Weissman, G L Klerman

  • 1New York State Psychiatric Institute, NY 10032.

Archives of General Psychiatry
|September 1, 1990
PubMed
Summary
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This study found that individuals with uncomplicated panic disorder have a significantly higher risk of suicide attempts, comparable to major depression. This highlights the importance of recognizing panic disorder

Area of Science:

  • Epidemiology
  • Psychiatry
  • Public Health

Background:

  • Previous research indicated a link between panic disorder and suicide attempts.
  • The risk associated with uncomplicated panic disorder (without other Axis I disorders) required further investigation.

Purpose of the Study:

  • To estimate the risk of suicide attempts in individuals with uncomplicated panic disorder.
  • To compare this risk with those having comorbid panic disorder and uncomplicated major depression.

Main Methods:

  • Analysis of data from the Epidemiologic Catchment Area study, a large-scale survey of over 18,000 adults.
  • Statistical control for comorbidity with other psychiatric disorders.

Main Results:

  • Lifetime suicide attempt rates were 7% for uncomplicated panic disorder, compared to 1% for individuals with no psychiatric disorder.

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  • Suicide attempt rates for uncomplicated major depression were similar (7.9%).
  • Risks were comparable between uncomplicated panic disorder, comorbid panic disorder, and uncomplicated major depression.

    • Conclusions:

    • Suicide attempts are associated with panic disorder, regardless of comorbidity.
    • The risk of suicide attempts in panic disorder is comparable to that of major depression.
    • Clinical presentation may obscure the association between panic disorder and suicide attempts.