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Related Experiment Video

Updated: May 9, 2026

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Determinants of novel object and location recognition during development.

S A Jablonski¹, W B Schreiber, S R Westbrook

¹Psychology Department, University of Delaware, Newark, DE 19716, USA.

Behavioural Brain Research

|August 13, 2013

Summary

Young rats can recognize novel objects and locations by postnatal day 21. NMDA receptor function is crucial for object location memory, but neonatal alcohol exposure does not impair performance in these tasks.

Keywords:

BAC CPFE FASDs Fetal alcohol spectrum disorder GD Hippocampus NMDA Receptor NMDA-receptor NMDAr OL OR OiP Ontogeny PD SI Spatial cognition blood alcohol concentration context preexposure facilitation effect fetal alcohol spectrum disorders gestational day object location task object recognition task object-in-place task postnatal day sham intubated

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Last Updated: May 9, 2026

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Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Area of Science:

Neuroscience
Developmental Psychology
Animal Behavior

Background:

Novel Object Recognition (OR) and Object Location (OL) tasks assess memory in rats.
Previous studies on spatial memory ontogeny in rats have yielded conflicting results.
Hippocampal lesions impair OL but not OR, suggesting a role for spatial memory in OL.

Purpose of the Study:

Characterize OR and OL tasks in developing rats (postnatal days 21, 26, 31).
Investigate the role of NMDA receptor systems in OR and OL performance.
Examine the impact of neonatal alcohol exposure on OR and OL tasks.

Main Methods:

Behavioral testing of rats aged PD21, PD26, and PD31 in OR and OL paradigms.
Pharmacological manipulation of NMDA receptor systems during memory acquisition.
Assessment of OR and OL performance in rats exposed to alcohol neonatally.

Main Results:

Rats at PD21 demonstrate proficiency in both OR and OL tasks, with higher novelty preference in OR.
NMDA receptor activity is essential for OL memory acquisition but not OR in juvenile rats.
Neonatal alcohol exposure did not significantly affect performance in either the OR or OL tasks.

Conclusions:

Developing rats acquire incidental spatial learning abilities by postnatal day 21.
NMDA receptor-dependent mechanisms are critical for the development of object location memory.
Neonatal alcohol exposure, under these conditions, does not appear to disrupt early spatial and object recognition memory development.