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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

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Controlling periodontal bone levels with multiple LED irradiations.

Po-Chun Chang¹, Chen-Ying Wang, Li Yen Chong

¹Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, 1 Chang-Te St, Taipei 100, Taiwan, changpc@ntu.edu.tw.

Lasers in Medical Science

|August 13, 2013

Summary

Multiple low-level laser therapy (LLLT) sessions using 660 nm LED light improved periodontal bone level and reduced inflammation in rats for up to seven days. Three weekly LLLT sessions showed the most significant periodontal regenerative effects.

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Area of Science:

Periodontology
Biomedical Engineering
Regenerative Medicine

Background:

Single exposure to 660 nm LED irradiation offers limited 3-day biostimulatory effects on periodontal bone level (PBL).
Investigating extended therapeutic effects of multiple LED irradiations is crucial for sustained periodontal regeneration.

Purpose of the Study:

To evaluate if multiple light-emitting diode (LED) irradiations can extend the periodontal biostimulatory effects.
To assess the impact of varying frequencies of LED irradiation on periodontal healing.

Main Methods:

Experimental periodontitis was induced in Sprague-Dawley rats using ligatures and lipopolysaccharide injections.
Animals received debridement and detoxification, followed by 0, 1, 2, or 3 weekly sessions of 660 nm LED irradiation (10 J/cm²).
Periodontal parameters were evaluated using micro-computed tomography and histology at 7 and 14 days post-treatment.

Main Results:

Three weekly LED irradiations significantly reduced PBL, inflammation, and gingival hyperplasia by day 7.
By day 14, gingival hyperplasia reduction remained significant, with accelerated collagen deposition and realignment, though PBL differences were not significant.
The three-irradiation regimen extended PBL and inflammation reduction effects to 7 days.

Conclusions:

A treatment regimen of three 660 nm LED irradiations per week demonstrates extended periodontal regenerative effects, particularly in reducing inflammation and hyperplasia.
While promising for short-term periodontal stability, additional strategies are needed to maintain long-term bone levels and healing.
Future research should explore adjunct therapies or bioactive signals to enhance sustained periodontal repair.