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Translating translational research: mouse models of human disease

Amanda M Burkhardt1, Albert Zlotnik

  • 1Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, USA.

Cellular & Molecular Immunology
|August 13, 2013
PubMed
Abstract

No abstract available in PubMed .

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Mouse Models of Cancer Study02:43

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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