Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer treatment-related cognitive impairment.

Neuro-oncology advances·2026
Same author

Long-term cognitive function after treatment with immune checkpoint inhibition for melanoma.

Journal of cancer survivorship : research and practice·2026
Same author

Neuropsychological sequelae of cancer and cancer therapy.

Journal of clinical and experimental neuropsychology·2025
Same author

Cognitive function during endocrine treatment with or without cyclin-dependent kinase 4/6 inhibitors for advanced breast cancer.

Cancer·2025
Same author

Dementia and Cancer: Unravelling Methodological Biases in a Population-Based Cohort.

Neuroepidemiology·2025
Same author

Psychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors.

Translational psychiatry·2025

Related Experiment Video

Updated: May 8, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Functional MRI studies in non-CNS cancers.

Michiel B de Ruiter1, Sanne B Schagen

  • 1Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands, m.d.ruiter@nki.nl.

Brain Imaging and Behavior
|August 13, 2013
PubMed
Summary

Systemic cancer treatments can cause cognitive problems. Functional magnetic resonance imaging (fMRI) reveals altered brain activity in cancer survivors, indicating potential neurotoxicity from chemotherapy and other treatments.

More Related Videos

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
12:27

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures

Published on: October 20, 2009

Related Experiment Videos

Last Updated: May 8, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
12:27

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures

Published on: October 20, 2009

Area of Science:

  • Neuroscience
  • Oncology
  • Radiology

Background:

  • Cognitive impairments are an increasing concern for cancer survivors due to improved survival rates.
  • Systemic treatments for non-central nervous system (non-CNS) cancers can lead to neurotoxic side effects.
  • Functional magnetic resonance imaging (fMRI) offers a noninvasive method to investigate the neural basis of these cognitive issues.

Purpose of the Study:

  • To review and synthesize findings from published fMRI studies on neurotoxic effects of systemic cancer treatment.
  • To identify patterns of brain activation changes associated with cognitive deficits in cancer survivors.
  • To highlight limitations and suggest future research directions in the field.

Main Methods:

  • Systematic review of 14 published fMRI studies focusing on systemic treatment side effects in non-CNS cancers.
  • Analysis of cross-sectional and prospective studies in breast and prostate cancer survivors.
  • Examination of brain activation patterns during executive functioning and episodic memory tasks.

Main Results:

  • Consistent hypoactivation in prefrontal and parietal regions observed in breast cancer survivors years after chemotherapy, linked to poorer cognitive performance.
  • Evidence of impaired memory encoding (hypoactivation) compensated by enhanced retrieval (hyperactivation).
  • Preliminary findings in prostate cancer patients suggest reduced activation after androgen deprivation therapy.

Conclusions:

  • Systemic cancer treatments, including chemotherapy and androgen deprivation therapy, appear to impact neural functioning, leading to cognitive problems.
  • Observed brain activation patterns (hypo- and hyperactivation) suggest complex neural adjustments and potential long-term neurotoxicity.
  • Future research requires larger sample sizes, robust statistical correction, comprehensive neurocognitive testing, and multimodal MRI for clearer interpretation.