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Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently

Altan Onat1, Günay Can, Ender Örnek

  • 1Turkish Society of Cardiology and Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey, alt_onat@yahoo.com.tr.

Clinical Rheumatology
|August 13, 2013
PubMed

Insights

Elevated serum uric acid (UA) indicates a pro-inflammatory state and HDL dysfunction in nondiabetic individuals. High UA levels independently predict coronary heart disease (CHD) risk in men, modulated by metabolic syndrome and gender.

Area of Science:

  • Cardiovascular Disease Research
  • Metabolic Health Studies
  • Biomarker Analysis

Background:

  • Serum uric acid (UA) is increasingly recognized as a potential factor in metabolic and cardiovascular health.
  • Understanding the relationship between UA, inflammation, and high-density lipoprotein (HDL) function is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the association between serum uric acid concentrations and pro-inflammatory markers and HDL dysfunction.
  • To determine if serum UA predicts incident coronary heart disease (CHD) in nondiabetic individuals.

Main Methods:

  • Cross-sectional analysis of UA tertiles in 1,508 nondiabetic participants.
  • Longitudinal follow-up for incident CHD using Cox proportional hazards regression.
  • Linear regression to identify covariates of UA levels.

Main Results:

  • In nondiabetic individuals without metabolic syndrome (MetS), higher UA tertiles correlated with increased inflammation and apolipoprotein B, and decreased smoking.
  • These associations attenuated in the presence of MetS.
  • Elevated UA independently predicted incident CHD in men (HR 2.7), but not in women, and was linked to triglycerides and HDL dysfunction.

Conclusions:

  • Elevated serum UA is associated with a pro-inflammatory state and HDL dysfunction in nondiabetic individuals.
  • Serum UA is an independent predictor of CHD risk in nondiabetic men, with modulation by MetS and gender.

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