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Published on: November 1, 2015
Turkish lupusPRO: cross-cultural validation study for lupus
Arif Kaya1, Berna Goker, Elife Senem Cura
1Department of Internal Medicine, Division of Rheumatology, Gazi University Medical Faculty, Ankara, Turkey, arifkayadr@yahoo.com.
Clinical Rheumatology
|August 13, 2013
Summary
The Turkish LupusPRO is a validated patient-reported outcome measure for systemic lupus erythematosus (SLE). This study confirms its reliability and validity for Turkish patients, enabling its use in clinical research.
Area of Science:
- Rheumatology
- Clinical Research Methodology
- Health Outcomes Research
Background:
- Systemic lupus erythematosus (SLE) requires reliable patient-reported outcome measures (PROMs) for effective management and research.
- The LupusPRO was previously developed and validated in US patients with SLE.
- Cross-cultural adaptation and validation are crucial for extending the utility of PROMs to diverse patient populations.
Purpose of the Study:
- To cross-culturally adapt and validate the Turkish version of the LupusPRO in patients with SLE.
- To assess the reliability (internal consistency and test-retest) and validity (convergent and criterion) of the Turkish LupusPRO.
- To evaluate the conceptual framework and item-to-scale relationships of the Turkish LupusPRO.
Main Methods:
- The Turkish LupusPRO and SF-36 (Turkish) were administered to 102 Turkish SLE patients.
- Disease activity was assessed using physician global assessment (PGA), SELENA-SLEDAI, and LFA flare.
- Disease damage was measured by the SDI. Test-retest reliability was assessed using a second LupusPRO administration within 2-3 days.
- Confirmatory factor analysis was used to evaluate the conceptual framework.
Main Results:
- The Turkish LupusPRO demonstrated good test-retest reliability (0.87–0.97) and internal consistency reliability (0.63–0.94).
- Convergent validity was established with the SF-36, and criterion validity was supported by correlations with disease activity measures (PGA, SLEDAI, LFA flare) and overall health status (SF-6D).
- Confirmatory factor analysis indicated satisfactory model fit for the hypothesized item-to-scale relationships.
Conclusions:
- The Turkish version of the LupusPRO is a valid and reliable patient-reported outcome measure for SLE.
- It performs comparably to the English and Spanish versions, supporting its use in Turkish clinical trials and longitudinal studies.
- The validated Turkish LupusPRO can effectively assess patient-reported outcomes in SLE research within the Turkish population.
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