Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette
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Updated: May 8, 2026

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
Published on: March 13, 2016
Boaz Vilozny1, Alexander L Wollenberg, Paolo Actis
1Department of Biomolecular Engineering, Baskin School of Engineering at University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. pourmand@soe.ucsc.edu.
Abstract:
Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic acid groups, undergoes a transition from swollen to collapsed upon binding to monosaccharides. As a result, the current rectification in nanopipettes can be reversibly switched depending on the concentration of monosaccharides. Such molecular actuation of nanofluidic conductance may be used in novel sensors and drug delivery systems.

