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Updated: May 8, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
Abstract:
A growing global movement argues for health to take center stage in the post-2015 sustainable human development agenda, building on the Millennium Development Goals and improving measurement of outcomes and equity. Considered key is the urgent need to effectively stem chronic noncommunicable diseases (NCDs). The reasoning is straightforward and yet addresses the interactive complexities of NCD impact and the potential synergies to reduce it: NCDs constitute the most important, if until recently neglected, pandemic of our era. They accounted for over 65% of global deaths and 54% of the global disease burden in 2010.[1,2] Such a negative "contribution" -including the sequelae of disability and alarming costs of treatment for multimorbidities associated with aging populations worldwide-jeopardizes sustainable human development.
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