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Updated: May 8, 2026
10:23
A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
[Tumor-induced hypercalcemia]
O Hopfer1, A Gawliczek, M G Kiehl
1Medizinische Klinik I mit Schwerpunkt Hämatologie, Internistische Onkologie und Pulmologie, Klinikum Frankfurt Oder GmbH, Müllroser Chaussee 7, 15236, Frankfurt Oder, Deutschland. olaf.hopfer@klinikumffo.de
Der Internist
|August 13, 2013
Summary
Hypercalcemia, often a sign of advanced cancer, causes symptoms like neurological and renal issues. Treatment focuses on fluids, diuresis, and medications like bisphosphonates to lower calcium levels.
Area of Science:
- Endocrinology
- Oncology
- Nephrology
Context:
- Hypercalcemia is frequently linked to advanced malignant diseases.
- It results from increased bone resorption and reduced renal calcium excretion.
- Elevated calcium levels can manifest asymptomatically or with severe systemic symptoms.
Purpose:
- To outline the diagnostic approaches for hypercalcemia.
- To detail the therapeutic strategies for managing hypercalcemia.
- To emphasize the importance of considering symptom severity and calcium level trends.
Summary:
- Diagnostic evaluation includes serum albumin and ionized calcium levels.
- Management principles involve fluid replacement and diuresis.
- Pharmacological interventions such as calcitonin, bisphosphonates, and steroids are crucial for reducing plasma calcium.
Impact:
- Provides a concise overview of hypercalcemia diagnosis and management.
- Highlights the clinical significance of hypercalcemia in oncology.
- Aids clinicians in optimizing patient care for hypercalcemic conditions.
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