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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
06:46

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Published on: January 16, 2013

Antimicrobial therapy for chronic bacterial prostatitis.

Gianpaolo Perletti1, Emanuela Marras, Florian M E Wagenlehner

  • 1Laboratory of Toxicology and Pharmacology, Biomedical Research Division, Dept. of Theoretical and Applied Sciences, Università degli Studi dell'Insubria, Via A. da Giussano, 10, Busto A, Province of Varese, Italy, 21052.

The Cochrane Database of Systematic Reviews
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

This study found that oral fluoroquinolones are equally effective and safe for treating chronic bacterial prostatitis (CBP). Macrolides showed better results for CBP caused by intracellular pathogens.

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Area of Science:

  • Urology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic bacterial prostatitis (CBP) affects men of fertile age, causing pain, voiding issues, and sexual dysfunction.
  • Long-term antibiotic therapy is used for CBP, but relapses are common due to poor drug penetration into prostatic tissue.
  • Fluoroquinolones, macrolides, tetracyclines, and trimethoprim are key agents for CBP treatment.

Purpose of the Study:

  • To compare the efficacy and safety of various antimicrobial treatments for chronic bacterial prostatitis.
  • To evaluate different antimicrobial agents, doses, durations, and administration routes for CBP.

Main Methods:

  • Conducted a systematic review of randomized controlled trials from CENTRAL, MEDLINE, and EMBASE databases.
  • Included studies comparing antimicrobial agents versus placebo or other antimicrobials for CBP.
  • Extracted data on microbiological and clinical efficacy, and adverse effects.

Main Results:

  • Eighteen studies with 2196 patients compared oral fluoroquinolones; no significant differences in efficacy or adverse effects were found.
  • In chlamydial prostatitis, azithromycin demonstrated superior eradication and cure rates compared to ciprofloxacin.
  • For ureaplasmal prostatitis, ofloxacin, minocycline, and azithromycin showed similar outcomes.

Conclusions:

  • Different oral fluoroquinolones exhibit comparable efficacy and safety profiles for CBP.
  • Optimal treatment duration for fluoroquinolones in CBP remains undetermined.
  • Macrolides are more effective than fluoroquinolones for CBP caused by obligate intracellular pathogens.