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Neuropathologic basis of white matter hyperintensity accumulation with advanced age

Deniz Erten-Lyons1, Randall Woltjer, Jeffrey Kaye

  • 1From the Department of Neurology (D.E.-L., J.K., L.C.S.), Veterans Affairs Medical Center, Portland, OR; and Departments of Neurology (D.E.-L., J.K., N.M., H.H.D., D.B.H., K.W., L.C.S.) and Pathology (R.W., S.G., H.T.), Oregon Health & Science University, Portland.

Neurology
|August 13, 2013
PubMed
Summary

Small vessel ischemic disease drives white matter hyperintensity (WMH) accumulation in aging. Alzheimer disease (AD) pathology also correlates with WMH, suggesting shared mechanisms like ischemia impact brain health.

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