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Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon
Paul S Redford1, Katrin D Mayer-Barber, Finlay W McNab
1Division of Immunoregulation, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London.
Abstract:
Influenza followed by severe acute bacterial pneumonia is a major cause of mortality worldwide. Several mechanisms account for this enhanced susceptibility, including increased production of type I interferon (IFN). In individuals infected with Mycobacterium tuberculosis, the influence of acute viral infections on tuberculosis progression is unclear. We show that prior exposure of mice to influenza A virus, followed by M. tuberculosis infection, leads to enhanced mycobacterial growth and decreased survival. Following M. tuberculosis/influenza virus coinfection, mycobacterial growth is enhanced by a type I IFN signaling pathway. Our findings highlight the detrimental influence influenza virus infection can have before or during M. tuberculosis infection.
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