Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Muscle glucose metabolism during exercise.

K Sahlin1

  • 1Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.

Annals of Medicine
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strength training improves muscle aerobic capacity and glucose tolerance in elderly.

Scandinavian journal of medicine & science in sports·2015
Same author

Adding strength to endurance training does not enhance aerobic capacity in cyclists.

Scandinavian journal of medicine & science in sports·2014
Same author

The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle.

Acta physiologica (Oxford, England)·2011
Same author

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes.

Diabetologia·2010
Same author

Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training.

Diabetes, obesity & metabolism·2009
Same author

Turning down lipid oxidation during heavy exercise--what is the mechanism?

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2009

Exercise intensity and duration significantly impact fuel use, shifting from fat to carbohydrates. Oxygen availability and muscle contraction also influence substrate utilization during physical activity.

Area of Science:

  • Exercise Physiology
  • Muscle Metabolism
  • Biochemistry

Background:

  • Substrate utilization during exercise is multifactorial, influenced by intensity, duration, training status, and substrate availability.
  • Fat oxidation dominates at rest and low intensities, while carbohydrate oxidation and anaerobic pathways are key at higher intensities.
  • Oxygen availability is a critical determinant of muscle metabolism during exercise.

Purpose of the Study:

  • To explore the determinants of substrate utilization during exercise.
  • To investigate the impact of hypoxia on muscle metabolism.
  • To understand the regulation of muscle glucose uptake during physical activity.

Main Methods:

  • Review of existing literature on substrate utilization during exercise.

Related Experiment Videos

  • Analysis of factors influencing energy source selection.
  • Examination of muscle glucose uptake mechanisms.

    • Main Results:

    • Muscle glucose uptake increases significantly with exercise intensity and duration, correlating with liver glucose output.
    • Hypoxia mimics increased exercise intensity by altering substrate utilization.
    • Muscle contraction can stimulate glucose uptake independently of insulin; insulin and low-intensity exercise show synergistic effects.
    • Intracellular glucose concentrations can exceed utilization rates during intense exercise and hypoxia.

    Conclusions:

    • Oxygen availability is a crucial factor in muscle metabolism during exercise.
    • Muscle glucose uptake is dynamically regulated by exercise intensity, duration, and hormonal factors.
    • Under specific conditions like intense exercise and hypoxia, glucose uptake can surpass glucose utilization.