Related Experiment Video
Updated: May 8, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Physical fitness in children with type 1 diabetes measured with six-minute walk test
Vladimir Jegdic1, Zeljko Roncevic, Veselin Skrabic
1Department of Pediatrics, University Hospital, 88000 Mostar, Bosnia and Herzegovina.
Insights
Children with type 1 diabetes (T1D) demonstrate reduced physical fitness compared to healthy peers. Elevated HbA1c levels did not correlate with decreased fitness in these children.
Area of Science:
- Pediatrics
- Endocrinology
- Sports Medicine
Background:
- Type 1 diabetes (T1D) is a chronic condition affecting children.
- Physical fitness is crucial for overall health and well-being in pediatric populations.
- Understanding the impact of T1D on physical fitness is essential for comprehensive management.
Purpose of the Study:
- To compare the physical fitness of children with T1D to that of healthy controls.
- To investigate the association between glycated hemoglobin A1c (HbA1c) levels and physical fitness in children with T1D.
Main Methods:
- A case-control study involving 100 children with T1D (aged 7-17.9 years) and matched healthy controls.
- Physical fitness assessed using the 6-minute walk test (6MWT), measuring distance, heart rate, and oxygen saturation.
Main Results:
- Children with T1D walked significantly shorter distances (601.3m) than controls (672.1m) during the 6MWT (P < 0.001).
- Lower pulse oxygen saturation was observed in children with T1D at pretest (P < 0.001).
- HbA1c levels above 8% did not show a significant difference in physical fitness compared to those below 8% within the T1D group.
Conclusions:
- Children diagnosed with T1D exhibit diminished physical fitness compared to their healthy counterparts.
- Glycemic control, as indicated by HbA1c levels, did not appear to influence the physical fitness outcomes in this pediatric cohort.
Abstract:
Aim/Hypothesis. To examine whether children with DMT1 are less physically fit than healthy children and to assess whether an elevated level of HbA1c was associated with decreased physical fitness among children with diabetes. Methods. The study was conducted using case-control methodology. The cases were 100 children with T1DM, 7-17,9 years. Study subjects underwent a 6MWT, where distance measured, heart rate, and oxygen saturation was recorded. Results. Results of the 6MWT for children with T1DM and controls were 601.3 ± 86.1 meters versus 672.1 ± 60.6 meters, respectively (P < 0.001). The cases were divided into two subgroups, one with HbA1c levels >8% and one with HbA1c <8%. Results for both groups were inferior to the controls (P < 0.001). The posttest pulse rate in all subjects was higher than the pretest pulse rate (P < 0.001). Pulse oxygen levels were lower than controls at the pretest measurement (P < 0.001), and for both cases and controls, pulse oxygen levels decreased after test (P = 0.004). However, the change in oxygen saturation did not differ between the groups (P = 0.332). Conclusions. Children with T1D are less fit than matched controls. The level of HbA1c did not affect the physical fitness of children with T1D.
Related Concept Videos
Type I Diabetes III: Clinical Manifestations
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Type I Diabetes I: Introduction
Type I Diabetes II: Pathophysiology
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
