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Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 8, 2026

Isolating Immune Cells from Mouse Brain and Skull
06:28

Isolating Immune Cells from Mouse Brain and Skull

Published on: July 26, 2024

The Interplay between the bone and the immune system.

Giorgio Mori1, Patrizia D'Amelio, Roberta Faccio

  • 1Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.

Clinical & Developmental Immunology
|August 13, 2013
PubMed
Summary
This summary is machine-generated.

The immune system and bone cells are intricately linked, influencing each other

More Related Videos

Automated Quantification of Hematopoietic Cell &#8211; Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Related Experiment Videos

Last Updated: May 8, 2026

Isolating Immune Cells from Mouse Brain and Skull
06:28

Isolating Immune Cells from Mouse Brain and Skull

Published on: July 26, 2024

Automated Quantification of Hematopoietic Cell &#8211; Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Area of Science:

  • Immunology
  • Bone Biology
  • Osteoimmunology

Background:

  • Bone and immune cells share developmental pathways and regulatory mechanisms.
  • Osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells) are influenced by immune mediators.
  • The field of osteoimmunology studies these complex interactions.

Purpose of the Study:

  • To review the latest findings on the reciprocal regulation between bone and immune cells.
  • To highlight the significance of osteoimmunology for understanding diseases.

Main Methods:

  • Literature review of recent scientific findings.
  • Synthesis of information on cellular and molecular interactions.

Main Results:

  • Demonstrated shared myeloid precursors for osteoclasts and immune cells.
  • Illustrated how osteoblasts regulate hematopoietic stem cell niches.
  • Detailed the role of cytokines and growth factors in bone cell activity.

Conclusions:

  • The interplay between bone and immune systems is crucial for health.
  • Osteoimmunology research offers insights into disease pathogenesis.
  • Understanding these interactions can lead to new therapeutic strategies.